PTPL 1 / PTPN 13 regulates breast cancer cells aggressiveness through direct inactivation of Src kinase
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PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase.
The protein tyrosine phosphatase PTPL1/PTPN13, the activity of which is decreased through allelic loss, promoter methylation, or somatic mutations in some tumors, has been proposed as a tumor suppressor gene. Moreover, our recent clinical study identified PTPL1 expression level as an independent prognostic indicator of a favorable outcome for patients with breast cancer. However, how PTPL1 can ...
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تاریخ انتشار 2010